What is the Entourage Effect: Everything you need to know

The entourage effect image

In recent years, there has been a surge of usage in various hemp-derived compounds and their combination, particularly CBD (cannabidiol) and THC (tetrahydrocannabinol) for their wellness potential.

However, one intriguing concept that has emerged from this research is the “entourage effect.”

The entourage effects have important implications for people who use hemp-derived products, whether for medical reasons or simply for enjoyment. It suggests that when various compounds in hemp, like CBD and THC, come together, they can create unique and potentially stronger effects.

 In this article, we’ll delve into the concept of the entourage effect, its underlying mechanisms, the compounds involved, its benefits, and how you can get the most out of it.

What is the entourage effect?

The entourage effect explained in image

The entourage effect is a concept coined to explain the synergistic interaction of numerous compounds present in hemp and cannabis plants that work together to produce a range of therapeutic benefits that are more effective than what any compound could achieve on its own. 

To clarify, a hemp plant has a wide range of compounds such as cannabinoids, flavonoids, and terpenes. These compounds have unique abilities which are effective on their own. However, when they come together in a product, they don’t just add up their effects – they enhance each other’s strengths; this is called the entourage effect.

What does the research say about the entourage effect?​

Scientific research is still in its early stages, but there is a growing body of evidence supporting its validity, especially in treating mood and anxiety disorders (1). Studies have shown that when multiple cannabinoids and other compounds of a plant are combined, they can influence each other’s effects, potentially enhancing the overall therapeutic benefit. 

One landmark study published in the British Journal of Pharmacology in 2011 found that a combination of THC and CBD was more effective in reducing pain and muscle spasticity in multiple sclerosis patients than THC alone. 

This suggests that the entourage effect plays a crucial role in optimizing the wellness potential of hemp-derived products.

How does the entourage effect work?

Think of the entourage effect as teamwork among different compounds that are present in hemp-derived products. It’s like when you use a product that has many different cannabinoids and terpenes, they work together in a synergy in your body.

For example, CBD can mitigate the strong psychoactive effects of THC and some terpenes can make pain relief work even better. It’s like they help each other out. This teamwork leads to a stronger and more well-rounded overall effect.

Which compounds are involved in the entourage effect?


CBD (cannabidiol) and THC (tetrahydrocannabinol) are the most well-known cannabinoids. Each has distinct effects, for example, CBD helps with stress and anxiety, while THC produces a high. They interact with receptors in your body to influence various functions. However, there are over 100 different cannabinoids in hemp plants that also contribute to the entourage effect. Some notable ones include:

  • CBG (Cannabigerol): Known for its potential anti-inflammatory and antibacterial properties.
  • CBN (Cannabinol): Often associated with sedative effects, meaning it can help you with sleep.
  • CBC (Cannabichromene): It can offer anti-anxiety, antidepressant, pain-relieving, antiviral, tumor-busting, and bone-growth-stimulating qualities.
  • THCV (Tetrahydrocannabivarin): It has appetite-suppressing and neuroprotective properties.


These are aromatic compounds responsible for the different scents and flavors you find in hemp and cannabis strains. Beyond adding aroma and taste, some terpenes can help you relax, while others can make you feel more alert. Some terpenes can also add depth and complexity to the overall experience and are crucial contributors to the entourage effect.

 There are over 200 different types of terpenes. Some common ones include:

  • Myrcene: Known for its earthy and musky aroma, it can also promote relaxation.
  • Limonene: Offers a citrusy scent and can have mood-elevating and stress-relieving effects. 
  • Pinene: Provides a piney aroma and has anti-inflammatory properties.


Flavonoids are plant compounds that contribute to the colors and flavors of a product. While they are not as widely studied as cannabinoids and terpenes, they can also have therapeutic properties. 

For example, some flavonoids can also have antioxidant and anti-inflammatory effects, further enhancing the overall impact of hemp products and contributing to the entourage effect.

Other compounds:

In addition to cannabinoids, terpenes, and flavonoids, other minor compounds in hemp also contribute to the entourage effect. These can include essential fatty acids, vitamins, and minerals. While their roles are less understood, they can play a part in enhancing the overall benefits of hemp-derived products.

How do you experience the entourage effect?

Choose full-spectrum and broad-spectrum CBD products:

The first step in experiencing the entourage effect is selecting full-spectrum and broad-spectrum products. Full-spectrum means that the product contains a broad range of compounds that are naturally present in the hemp plant. This includes various cannabinoids like CBD and THC, as well as terpenes, flavonoids, and other minor compounds that will help you experience the benefits of the entourage effect.

However, if you are concerned with THC, you can opt for broad-spectrum CBD products as they also let you experience the entourage effect, but their effects are milder as compared to full-spectrum.

Experiment with different delivery methods:

Cannabis and hemp-derived products come in various forms, including oils, capsules, edibles, topicals, and more. Each delivery method can offer a different experience of the entourage effect. 

For instance, a CBD oil infused with specific terpenes may provide a distinct sensation as compared to a CBD-infused edible. Experimenting with different delivery methods will allow you to find the one that best suits your preferences and requirements.

Final thoughts

The entourage effect is an exciting and evolving concept in the world of hemp, and CBD. While more studies are needed to fully understand its mechanisms and potential, the evidence so far suggests that the therapeutic potential of these products extends far beyond the individual effects of single compounds.

As the science of hemp plant compounds continues to advance, the entourage effect shows promises to be an essential consideration for those seeking the most effective experience from the hemp-derived cannabinoids.


The information in this article is intended for general use only and may not always be appropriate for everyone’s needs. Your health and wellness are unique to you, so before acting on anything we say, seek personalized advice from a medical professional.

We value the accuracy and editorial integrity of all our articles, and we strive to ensure that the content we publish is accurate and up-to-date to the best of our knowledge.

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